FCRL1 Q96LA6

Fc受体样蛋白1 (FcR样蛋白1) (FcRL1) (Fc受体同源物1) (FcRH1) (IFGP家族蛋白1) (hIFGP1) (免疫受体易位相关蛋白5) (CD抗原CD307a)

功能描述

I型跨膜表面糖蛋白，优先由B细胞表达，调节BCR介导的信号应答 (PubMed:15479727)。招募ABL1作为胞内效应分子以增强B细胞活化 (By similarity)。还在稳态和BCR刺激条件下以GRB2依赖性方式抑制ERK活化，从而发挥负向作用 (By similarity)。 {ECO:0000250|UniProtKB:Q8R4Y0, ECO:0000269|PubMed:15479727}。

组织特异性

Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).

亚细胞定位

Cell membrane