FBXO44 Q9H4M3

仅含F-box蛋白44 (F-box蛋白FBX30) (F-box/G-domain蛋白3)

蛋白质信息 (UniProt)

仅含F-box蛋白44 (F-box蛋白FBX30) (F-box/G-domain蛋白3)

Q9H4M3

功能描述

两种不同E3连接酶复合物的底物识别成分，即SKP1-CUL1-FBXO44复合物和CUL4B-DDB1-FBXO44复合物 (PubMed:18203720, PubMed:25970626)。SCF(FBXO44)复合物泛素化并介导BRCA1降解 (PubMed:23086937)。与cullin 4B/CUL4B和DDB1结合，介导RGS2的泛素化导致其降解 (PubMed:25970626)。此外，通过泛素化和降解调节孕烷X受体/Nr1i2蛋白水平 (PubMed:37969738)。 {ECO:0000269|PubMed:23086937, ECO:0000269|PubMed:25970626, ECO:0000269|PubMed:37969738}。

组织特异性

Abundantly expressed in brain and kidney. Expressed at lower levels in heart, spleen and liver.

亚细胞定位

Nucleus

关键词

3D-structure Alternative splicing Nucleus Proteomics identification Reference proteome Ubl conjugation pathway

外部链接

UniProt: Q9H4M3

NCBI Gene

GeneCards