FBN2 P35556

原纤维蛋白-2 [剪切为：胎盘素]

功能描述

[Fibrillin-2]: Fibrillins是10-12 nm胞外钙结合微纤维的结构成分，其与elastin结合或以不含elastin的束状形式存在。含Fibrillin-2的微纤维调节弹性纤维组装的早期过程。通过控制TGF-beta的生物利用度并分别校准TGF-beta和BMP水平来调节成骨细胞成熟。 {ECO:0000250|UniProtKB:Q61555}.; FUNCTION: [Placensin]: 由滋养层细胞分泌的激素，促进滋养层细胞的侵袭能力 (PubMed:32329225)。具有生糖活性：能够增加血浆葡萄糖水平 (By similarity)。 {ECO:0000250|UniProtKB:Q61555, ECO:0000269|PubMed:32329225}.

组织特异性

Almost exclusively expressed in placenta (PubMed:32329225). Expressed at much lower level in other tissues (PubMed:32329225). Expressed in fetal eye (18 weeks)in the retinal pigment epithelium (RPE), the choroid, Bruch's membrane and in the sclera (PubMed:24899048). Not expressed in the neural retina (PubMed:24899048).

亚细胞定位

Secreted