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FASTKD2 Q9NYY8

含FAST激酶结构域蛋白2,线粒体

蛋白质信息 (UniProt)

含FAST激酶结构域蛋白2,线粒体

Q9NYY8

功能描述

在线粒体核糖体大亚基的组装中发挥重要作用 (PubMed:25683715)。作为由RCC1L、NGRN、RPUSD3、RPUSD4、TRUB2、FASTKD2和16S线粒体核糖体RNA (16S mt-rRNA)组成的功能性protein-RNA模块的组分,控制16S mt-rRNA的丰度,并且是线粒体内翻译所必需的 (PubMed:25683715, PubMed:26370583, PubMed:27667664)。可能在线粒体凋亡中发挥作用。 {ECO:0000269|PubMed:18771761, ECO:0000269|PubMed:25683715, ECO:0000269|PubMed:26370583, ECO:0000269|PubMed:27667664}。

组织特异性

Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid.

亚细胞定位

Mitochondrion matrix, mitochondrion nucleoid

关键词

Alternative splicing Disease variant Mitochondrion Mitochondrion nucleoid Phosphoprotein Primary mitochondrial disease Proteomics identification Reference proteome Ribosome biogenesis RNA-binding