FAM168B A1KXE4

髓鞘相关神经突生长抑制剂 (Mani) (p20)

功能描述

神经元轴突生长的抑制剂。作为CDC42和STAT3的负调节因子以及STMN2的正调节因子。CDC27的正调节因子。{ECO:0000250|UniProtKB:D4AEP3}。

组织特异性

Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level).

亚细胞定位

Cytoplasm, perinuclear region