FAIM2 Q9BWQ8

Lifeguard蛋白2 (Fas凋亡抑制分子2) (神经膜蛋白35) (含跨膜BAX抑制基序蛋白2)

功能描述

抗凋亡蛋白，独特地保护细胞免受Fas诱导的细胞凋亡。通过干扰caspase-8激活来调节神经元中Fas介导的细胞凋亡。可能通过影响小脑大小、内颗粒层(IGL)厚度和浦肯野细胞(PC)发育，在小脑发育中发挥作用。 {ECO:0000269|PubMed:10535980, ECO:0000269|PubMed:17635665}。

组织特异性

Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.

亚细胞定位

Cell membrane