EZR P15311

埃兹林 (细胞绒毛蛋白) (绒毛蛋白-2) (p81)

功能描述

可能参与主要细胞骨架结构与质膜的连接。在上皮细胞中，是顶端极微绒毛和膜皱褶形成所必需的。与PLEKHG6一起，是正常巨胞饮作用所必需的。 {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}。

组织特异性

Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.

亚细胞定位

Apical cell membrane