EZHIP Q86X51

EZH抑制蛋白

功能描述

通过抑制EZH1/EZH2甲基转移酶活性来抑制PRC2/EED-EZH1和PRC2/EED-EZH2复合物功能，从而导致组蛋白H3 'Lys-27' 三甲基化(H3K27me3)下调 (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685)。可能通过限制辅因子（如AEBP2和JARID2）的刺激作用来抑制甲基转移酶活性 (PubMed:30923826)。在精子发生和卵子发生过程中抑制H3K27me3沉积 (By similarity)。 {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}。

组织特异性

In testis, detected in male germ cells inside the seminiferous tubules, especially in spermatogonia and round spermatids (at protein level) (PubMed:31451685). In the ovary, expressed in primordial follicles and oocytes but not the external follicle cells (at protein level) (PubMed:31451685).

亚细胞定位

Nucleus