EPO P01588

促红细胞生成素 (Epoetin)

蛋白质信息 (UniProt)

促红细胞生成素 (Epoetin)

P01588

功能描述

参与调节红细胞增殖和分化以及维持循环红细胞质量生理水平的激素 (PubMed:28283061)。结合EPOR导致EPOR二聚化和JAK2激活，从而激活特定的下游效应因子，包括STAT1和STAT3 (PubMed:9774108)。 {ECO:0000269|PubMed:28283061, ECO:0000269|PubMed:9774108}。

组织特异性

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

亚细胞定位

Secreted

关键词

3D-structure Congenital erythrocytosis Direct protein sequencing Disease variant Disulfide bond Erythrocyte maturation Glycoprotein Hormone Pharmaceutical Proteomics identification

外部链接

UniProt: P01588

NCBI Gene

GeneCards