Ephrin B型受体 6 (HEP) (酪氨酸蛋白激酶缺陷型受体 EPH-6)
Ephrin B型受体 6 (HEP) (酪氨酸蛋白激酶缺陷型受体 EPH-6)
O15197功能描述
激酶缺陷型ephrin-B家族成员的受体。结合ephrin-B1和ephrin-B2。通过在ephrin-B2刺激下发挥正负双重效应来调节细胞粘附和迁移。在ephrin-B2刺激下，抑制JNK激活、T细胞受体诱导的IL-2分泌和CD25表达。 {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811}。
组织特异性
Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
亚细胞定位
Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted
关键词