EPB41L4B Q9H329

4.1样蛋白4B (红细胞膜蛋白4.1样4B) (含FERM蛋白CG1) (蛋白EHM2)

功能描述

上调Rho鸟嘌呤核苷酸交换因子ARHGEF18的活性 (By similarity)。参与上皮细胞中环状肌动球蛋白带的调节 (PubMed:22006950)。在体外促进细胞粘附、迁移和运动，可能在伤口愈合中发挥作用 (PubMed:23664528)。可能在介导与类固醇诱导的细胞分化相关的细胞骨架变化中发挥作用 (PubMed:14521927)。 {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}.

组织特异性

Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927).

亚细胞定位

Cytoplasm