ENTPD4 Q9Y227

胞外核苷三磷酸二磷酸水解酶4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (高尔基UDP酶) (溶酶体类腺苷三磷酸双磷酸酶70 kDa) (尿苷二磷酸酶) (UDPase) (EC 3.6.1.42)

功能描述

[Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452). {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}.; FUNCTION: [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}. 翻译结果： FUNCTION: [Isoform 1]: 以钙或镁依赖性方式催化核苷三磷酸和二磷酸的水解，优先作用于嘧啶。优先水解UTP和TTP。AMP、ADP、ATP和UMP不是底物 (PubMed:10858452, PubMed:9556635)。被Ca(2+)激活优于Mg(2+) (PubMed:10858452)。 {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}.; FUNCTION: [Isoform 2]: 具有广泛的底物特异性，能够裂解除腺苷二磷酸和三磷酸（ADP和ATP）以外的所有核苷二磷酸和三磷酸。优先水解CTP、UDP、CDP、GTP和GDP。可以同等程度地利用Ca(2+)或Mg(2+)。 {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}.

组织特异性

Ubiquitous. Highest expression in testis and lowest in bladder.

亚细胞定位

[Isoform 1]: Cytoplasmic vesicle, autophagosome membrane