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ENTPD1 P49961

胞外核苷三磷酸二磷酸水解酶1 (EC 3.6.1.5) (ATP二磷酸水解酶) (ATP-DPH) (ATPDase) (胞外ATP二磷酸水解酶1) (胞外ATPDase 1) (胞外ATP酶1) (胞外腺苷三磷酸双磷酸酶) (淋巴细胞活化抗原) (核苷三磷酸二磷酸水解酶1) (NTPDase1) (CD抗原CD39)

蛋白质信息 (UniProt)

胞外核苷三磷酸二磷酸水解酶1 (EC 3.6.1.5) (ATP二磷酸水解酶) (ATP-DPH) (ATPDase) (胞外ATP二磷酸水解酶1) (胞外ATPDase 1) (胞外ATP酶1) (胞外腺苷三磷酸双磷酸酶) (淋巴细胞活化抗原) (核苷三磷酸二磷酸水解酶1) (NTPDase1) (CD抗原CD39)

P49961

功能描述

催化核苷三磷酸 (NTPs) 和核苷二磷酸 (NDPs) 的水解 (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251)。该酶分两步连续去除磷酸基团，通过 NDP 中间体将 NTPs 转化为核苷单磷酸 (NMPs) (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251)。该活性有助于调节细胞外核苷酸水平 (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251)。通过将促炎 ATP 和血小板激活 ADP 水解为 AMP，阻断血小板聚集并支持血流 (PubMed:8955160, PubMed:8996251)。 {ECO:0000269|PubMed:8529670, ECO:0000269|PubMed:8626624, ECO:0000269|PubMed:8955160, ECO:0000269|PubMed:8996251, ECO:0000305|PubMed:10636909}。

组织特异性

Expressed primarily on activated lymphoid cells (PubMed:7930580). Also expressed in endothelial tissues (PubMed:8955160). Highly expressed in placenta, lung, skeletal muscle, kidney (PubMed:8955160).

亚细胞定位

Membrane

关键词

Alternative splicing ATP-binding Calcium Direct protein sequencing Disease variant Disulfide bond Glycoprotein GTP-binding Hereditary spastic paraplegia Hydrolase

外部链接

UniProt: P49961
NCBI Gene