胞外NOX二硫键-硫醇交换蛋白2 (APK1抗原) (胞质卵巢癌抗原1) (肿瘤相关氢醌氧化酶) (tNOX) [包含：氢醌[NADH]氧化酶 (EC 1.-.-.-); 蛋白质二硫键-硫醇氧化还原酶 (EC 1.-.-.-)]
胞外NOX二硫键-硫醇交换蛋白2 (APK1抗原) (胞质卵巢癌抗原1) (肿瘤相关氢醌氧化酶) (tNOX) [包含：氢醌[NADH]氧化酶 (EC 1.-.-.-); 蛋白质二硫键-硫醇氧化还原酶 (EC 1.-.-.-)]
Q16206功能描述
可能参与细胞生长。可能作为质膜电子传递的末端氧化酶，将电子从细胞质NAD(P)H经氢醌传递给细胞表面的受体。氢醌氧化酶活性与蛋白质二硫键-硫醇互换/氧化还原酶活性交替进行，这可能控制与囊泡出芽或细胞增大相关的物理膜位移。这些活性以22分钟的周期振荡，并在调控超日细胞生物钟中发挥作用。 {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}。
组织特异性
Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
亚细胞定位
Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
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