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ENAH Q8N8S7

Enabled同源蛋白

蛋白质信息 (UniProt)

Enabled同源蛋白

Q8N8S7

功能描述

Ena/VASP蛋白是肌动蛋白相关蛋白,参与依赖于细胞骨架重塑和细胞极性的一系列过程,例如迁移细胞中的轴突导向以及片状伪足和丝状伪足的动力学。ENAH诱导成纤维细胞中富含F-肌动蛋白的突起形成。与BAIAP2-alpha协同作用,在NTN1下游促进丝状伪足形成(通过相似性)。 {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}。

组织特异性

Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions.

亚细胞定位

Cytoplasm. Cytoplasm, cytoskeleton

关键词

3D-structure Actin-binding Alternative splicing Cell junction Cell projection Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Phosphoprotein