EHF Q9NZC4

ETS同源因子 (hEHF) (含ETS结构域转录因子) (上皮特异性Ets转录因子3) (ESE-3)

功能描述

转录激活因子，可能在调节上皮细胞分化和增殖中发挥作用。可能作为ETS/AP-1应答基因特定亚群的阻遏因子，并作为细胞核对丝裂原活化蛋白激酶信号级联反应反应的调节因子。结合含有共有核苷酸核心序列GGAA的DNA序列。通过TNFRSF10B/DR5启动子上的Ets结合序列参与TNFRSF10B/DR5表达的调节。可能通过作为肿瘤抑制基因或抑癌基因促进发育和致癌作用。 {ECO:0000269|PubMed:10527851, ECO:0000269|PubMed:10644770, ECO:0000269|PubMed:11259407, ECO:0000269|PubMed:12444029, ECO:0000269|PubMed:17027647}.

组织特异性

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes.

亚细胞定位

Nucleus