EDNRA P25101

内皮素-1受体 (内皮素A型受体) (ET-A) (ETA-R) (hET-AR)

功能描述

内皮素-1的受体。通过与激活磷酸肌醇-钙第二信使系统的G蛋白结合来介导其作用。ET-A的结合亲和力排序为：ET1 > ET2 >> ET3。

组织特异性

Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.

亚细胞定位

Cell membrane; Multi-pass membrane protein.