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DUSP23 Q9BVJ7

双特异性蛋白磷酸酶 23 (EC 3.1.3.16) (EC 3.1.3.48) (低分子量双特异性磷酸酶 3) (LDP-3) (VH1样磷酸酶 Z)

蛋白质信息 (UniProt)

双特异性蛋白磷酸酶 23 (EC 3.1.3.16) (EC 3.1.3.48) (低分子量双特异性磷酸酶 3) (LDP-3) (VH1样磷酸酶 Z)

Q9BVJ7

功能描述

蛋白磷酸酶,介导在Tyr和Ser/Thr残基上磷酸化的蛋白质去磷酸化。在体外,它可以在体外去磷酸化p44-ERK1 (MAPK3),但不能去磷酸化p54 SAPK-beta (MAPK10)。能够增强JNK和p38 (MAPK14)的激活。 {ECO:0000269|PubMed:15147733, ECO:0000269|PubMed:15201283}。

组织特异性

Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.

亚细胞定位

Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.

关键词

3D-structure Cytoplasm Hydrolase Nucleus Protein phosphatase Proteomics identification Reference proteome