DSG4 Q86SJ6

桥粒芯糖蛋白-4 (钙黏蛋白家族成员 13)

功能描述

桥粒细胞-细胞连接的组分，这是细胞粘附正调控所必需的 (By similarity)。协调毛囊角质形成细胞从增殖到分化的转变 (By similarity)。在调节淋巴细胞向发炎皮肤迁移及维持表皮炎症反应稳态中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:Q6W3B0, ECO:0000250|UniProtKB:Q7TMD7}。

组织特异性

In scalp follicles, present in the inner root sheath (IRS) and all layers of the matrix and precortex (at protein level) (PubMed:12705872, PubMed:26173648). Expressed in the brain, muscle, kidney, pancreas, spleen, thymus and weakly expressed in the lung, liver, heart and placenta (PubMed:12705872). Highly expressed in skin, testis and prostate; less in salivary gland (PubMed:12648213).

亚细胞定位

Cell membrane