DSG3 P32926

桥粒芯糖蛋白-3 (130 kDa 寻常型天疱疮抗原) (PVA) (钙粘蛋白家族成员 6)

功能描述

桥粒细胞间连接的组分，这是细胞黏附正调控所必需的 (PubMed:31835537)。在角质形成细胞中，响应机械力进行黏附连接和桥粒连接组装所必需的 (PubMed:31835537)。对于静止期毛杆周围细胞和外根鞘上皮基底层细胞的桥粒介导的细胞间黏附是必需的，因此对于静止期毛发在毛囊中的锚定至关重要 (PubMed:9701552)。通过促进基底上层上皮细胞与基底细胞之间的桥粒介导的细胞间附着，维持上皮屏障所必需的 (By similarity)。可能在桥粒斑组分DSP、JUP、PKP1、PKP2和PKP3的蛋白稳定性方面发挥作用 (PubMed:22294297)。在角质形成细胞中，响应机械应变将YAP1定位在质膜上所必需的，这是通过形成由DSG3、PKP1和YWHAG组成的相互作用复合体来实现的 (PubMed:31835537)。可能还参与YAP1靶基因转录的正调控，从而影响细胞增殖 (PubMed:31835537)。与RAC1协同，通过皮层F-actin束的组织和肌动蛋白在紧密连接处的锚定，正调控细胞收缩性和细胞连接形成 (PubMed:22796473)。DSG3的胞质池对于CDH1和CTNNB1在发育中的黏附连接处的定位是必需的，可能通过调节SRC活性来实现 (PubMed:22294297)。通过抑制p38MAPK信号通路抑制角质形成细胞迁移，因此可能在调节伤口愈合中发挥作用 (PubMed:26763450)。 {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}。

组织特异性

Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level) (PubMed:19717567). Expressed in skin and mucosa (at protein level) (PubMed:22294297, PubMed:30528827). Expressed in the basal layer of the outer root sheath of the telogen hair club, specifically at the cell membrane between the apex of the cells and the surrounding hair club (at protein level) (PubMed:9701552). Expression is less abundant between the lateral margins of the outer root sheath basal cells (at protein level) (PubMed:9701552). Also expressed in the tongue, tonsil and esophagus (PubMed:16740002).

亚细胞定位

Cell membrane