DPT Q07507

真皮蛋白 (富含酪氨酸酸性基质蛋白) (TRAMP)

功能描述

似乎通过细胞表面整合素结合介导粘附。可能作为真皮成纤维细胞表面与其细胞外基质环境之间的通讯连接。增强TGFB1活性。抑制细胞增殖。加速胶原原纤维形成，并稳定胶原原纤维以防止低温解离（通过相似性）。{ECO:0000250}。

组织特异性

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.

亚细胞定位

Secreted, extracellular space, extracellular matrix