DOCK2 Q92608

细胞分裂因子蛋白2

功能描述

参与淋巴细胞响应趋化因子迁移所需的细胞骨架重排。作为鸟嘌呤核苷酸交换因子(GEF)发挥作用，通过交换结合的GDP为游离GTP来激活RAC1和RAC2，但不激活CDC42。可能还通过激活RAC2参与IL2的转录激活。 {ECO:0000269|PubMed:21613211}。

组织特异性

Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.

亚细胞定位

Endomembrane system