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DOCK10 Q96BY6

细胞分裂因子启动蛋白10 (Zizimin-3)

蛋白质信息 (UniProt)

细胞分裂因子启动蛋白10 (Zizimin-3)

Q96BY6

功能描述

鸟嘌呤核苷酸交换因子 (GEF),通过将结合的GDP交换为游离GTP来激活CDC42和RAC1。通过CDC42介导的途径,对Purkinje细胞和海马神经元中的树突棘形态发生至关重要。维持次级淋巴组织中的B细胞淋巴细胞生成并调节FCER2/CD23表达。 {ECO:0000250|UniProtKB:Q8BZN6}。

组织特异性

Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.

亚细胞定位

Nucleus

关键词

3D-structure Acetylation Alternative splicing Cell projection Cytoplasm Guanine-nucleotide releasing factor Nucleus Phosphoprotein Proteomics identification Reference proteome