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DNAJC27 Q9NZQ0

DnaJ同源亚家族C成员27 (Rab和DnaJ结构域包含蛋白)

蛋白质信息 (UniProt)

DnaJ同源亚家族C成员27 (Rab和DnaJ结构域包含蛋白)

Q9NZQ0

功能描述

GTPase,过表达时可激活MEK/ERK通路并诱导细胞转化。可能作为MAPK1的核支架,可能通过与MAPK1核输出信号结合,从而增强ERK1/ERK2信号传导。 {ECO:0000250|UniProtKB:Q8CFP6}。

组织特异性

Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers.

亚细胞定位

Nucleus

关键词

3D-structure Alternative splicing GTP-binding Nucleotide-binding Nucleus Oncogene Proteomics identification Reference proteome