DMTF1 Q9Y222

Cyclin-D结合Myb样转录因子1 (hDMTF1) (Cyclin-D相互作用Myb样蛋白1) (hDMP1)

功能描述

转录激活因子，在响应Ras-Raf信号传导时激活CDKN2A/ARF位点，从而促进p53/TP53依赖性生长停滞 (By similarity)。结合共有序列 5'-CCCG[GT]ATGT-3' (By similarity)。Isoform 1 可能与MYB协同激活ANPEP基因的转录。Isoform 2 可能拮抗 isoform 1 的转录激活。 {ECO:0000250, ECO:0000269|PubMed:12917399}。

组织特异性

Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.

亚细胞定位

Nucleus