DLG5 Q8TDM6

圆盘大同源蛋白5 (圆盘大蛋白P-dlg) (胎盘和前列腺DLG)

功能描述

作为Hippo信号通路的调节因子 (PubMed:28087714, PubMed:28169360)。通过介导MARK3与STK3/4的相互作用，将它们聚集在一起以促进依赖MARK3的STK3激酶活性（针对LATS1）的超磷酸化和失活，从而负向调节Hippo信号通路 (PubMed:28087714)。通过介导SCRIB与STK4/MST1和LATS1的相互作用正向调节Hippo信号通路，这对Hippo信号通路的激活很重要。参与调节细胞增殖、上皮极性的维持、上皮-间质转化 (EMT)、细胞迁移和侵袭 (PubMed:28169360)。在皮层神经元的树突棘形成和突触发生中起重要作用；通过增强N-cadherin的细胞表面定位来调节突触发生。作为hedgehog (Hh)信号通路的正调节因子。通过在纤毛基部与SMO相互作用，诱导KIF7和GLI2在纤毛顶端的积累以激活GLI2，从而在SMO活性循环的早期阶段发挥关键作用 (By similarity)。 {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}。

组织特异性

Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.

亚细胞定位

Cell junction