DEFB118 Q96PH6

防御素β118 (β-防御素18) (DEFB-18) (附睾分泌蛋白13.6) (ESP13.6)

功能描述

宿主防御肽，对革兰氏阴性菌（如E.coli和S.typhimurium）和革兰氏阳性菌（如S.aureus和B.subtilis）均表现出抗菌活性 (PubMed:15033915, PubMed:33224970)。抑制E.coli在肠上皮肠细胞上的细胞粘附 (PubMed:33224970)。引起E.coli外膜和内膜的快速透化，导致细菌表面形态改变 (PubMed:15033915)。以高亲和力结合细菌脂多糖 (LPS)，可能由此通过LPS中和参与免疫调节 (PubMed:33181266)。可能有助于附睾先天免疫并保护精子免受微生物攻击 (PubMed:15033915)。 {ECO:0000269|PubMed:15033915, ECO:0000269|PubMed:33181266, ECO:0000269|PubMed:33224970}。

组织特异性

High-level and epididymis-specific expression (PubMed:12600824). Most abundant in the epithelium of the caput and present in the epididymis lumen and bound to sperm (PubMed:12600824). Also expressed in pancreas (PubMed:12600824).

亚细胞定位

Secreted