β-防御素1 (BD-1) (hBD-1) (防御素，β 1)
β-防御素1 (BD-1) (hBD-1) (防御素，β 1)
P60022功能描述
具有杀菌活性。可能作为C-C趋化因子受体CCR6的配体。以CCR6依赖的方式正向调节精子运动能力和杀菌活性。结合CCR6并触发精子内的Ca2+动员，这对精子的运动能力很重要 (PubMed:25122636)。 {ECO:0000269|PubMed:25122636}。
组织特异性
Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
亚细胞定位
Secreted
关键词