DEDD2 Q8WXF8

含DNA结合死亡效应结构域蛋白2 (含DED蛋白FLAME-3) (FADD样抗凋亡分子3)

功能描述

可能在死亡受体诱导的细胞凋亡中起关键作用，并可能将CASP8和CASP10靶向至细胞核。可能在细胞凋亡过程中调节中间丝的降解。可能在细胞核内的通用转录机制中发挥作用，并且可能是GTF3C3活性的重要调节因子。

组织特异性

Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels.

亚细胞定位

Nucleus, nucleolus