DDR1 Q08345

上皮盘状结构域受体1 (上皮盘状结构域受体1) (EC 2.7.10.1) (CD167抗原样家族成员A) (细胞粘附激酶) (盘状结构域受体酪氨酸激酶) (HGK2) (乳腺癌激酶10) (MCK-10) (蛋白质-酪氨酸激酶3A) (蛋白质-酪氨酸激酶RTK-6) (TRK E) (酪氨酸激酶DDR) (酪氨酸-蛋白质激酶CAK) (CD抗原CD167a)

功能描述

酪氨酸激酶，作为原纤维胶原蛋白的细胞表面受体发挥作用，并调节细胞与细胞外基质的附着、细胞外基质的重塑、细胞迁移、分化、存活和细胞增殖。胶原蛋白结合触发涉及SRC的信号通路，并导致MAP激酶的激活。通过上调基质金属蛋白酶MMP2、MMP7和MMP9来调节细胞外基质的重塑，从而促进细胞迁移和伤口愈合。妊娠期正常囊胚植入、正常乳腺分化和正常泌乳所必需。正常耳形态和正常听力所必需 (By similarity)。促进平滑肌细胞迁移，从而有助于动脉伤口愈合。也在肿瘤细胞侵袭中发挥作用。磷酸化PTPN11。 {ECO:0000250, ECO:0000269|PubMed:12065315, ECO:0000269|PubMed:16234985, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed:19401332, ECO:0000269|PubMed:20093046, ECO:0000269|PubMed:20432435, ECO:0000269|PubMed:20884741, ECO:0000269|PubMed:21044884, ECO:0000269|PubMed:9659899}。

组织特异性

Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.

亚细胞定位

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted