DCUN1D1 Q96GG9

DCN1样蛋白1 (DCNL1) (含DCUN1结构域蛋白1) (Cullin neddylation缺陷蛋白1样蛋白1) (鳞状细胞癌相关癌基因)

功能描述

是一种用于neddylation的E3泛素连接酶复合物的组成部分 (PubMed:18826954)。促进E3 cullin-RING泛素连接酶复合物中cullin组分的neddylation (PubMed:19617556, PubMed:23201271, PubMed:23401859, PubMed:26906416)。通过在细胞质中结合cullin-RBX1复合物并促进其核易位，增强E2-NEDD8 (UBE2M-NEDD8) 硫酯向复合物的募集，并优化复合物中蛋白的取向以允许NEDD8从E2高效转移至cullin底物。参与解除CAND1对cullin-RING连接酶E3复合物组装和活性的抑制作用 (PubMed:25349211, PubMed:28581483)。还作为癌基因促进恶性转化和致癌进展 (By similarity)。 {ECO:0000250|UniProtKB:Q9QZ73, ECO:0000269|PubMed:18826954, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:23401859, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:28581483}.

组织特异性

Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

亚细胞定位

Nucleus