DCP1A Q9NPI6

mRNA脱帽酶1A (EC 3.6.1.62) (Smad4相互作用转录共激活因子) (转录因子SMIF)

蛋白质信息 (UniProt)

mRNA脱帽酶1A (EC 3.6.1.62) (Smad4相互作用转录共激活因子) (转录因子SMIF)

Q9NPI6

功能描述

mRNA降解所必需，参与正常的mRNA周转和无义介导的mRNA衰变 (PubMed:12417715)。去除mRNA分子的7-甲基鸟苷帽结构，产生5'-磷酸化mRNA片段和7m-GDP (PubMed:12417715)。在TGFB1刺激后有助于靶基因的反式激活 (PubMed:11836524)。对胚胎发育至关重要 (PubMed:33813271)。 {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}.

组织特异性

Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.

亚细胞定位

Cytoplasm, P-body

关键词

3D-structure Alternative splicing Cytoplasm Hydrolase Methylation Nonsense-mediated mRNA decay Nucleus Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q9NPI6

NCBI Gene

GeneCards