DCC P43146

Netrin受体DCC (结直肠癌抑制因子) (免疫球蛋白超家族DCC亚类成员1) (肿瘤抑制蛋白DCC)

功能描述

功能：netrin受体，为轴突导向所需。在发育中的神经系统中，配体结合后介导神经元生长锥的轴突吸引。其与UNC5蛋白的结合可能触发轴突排斥信号。当未与netrin配体结合时，它还作为诱导凋亡所需的依赖性受体起作用。暗示为一种抑癌基因。 {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}。

组织特异性

Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.

亚细胞定位

Membrane; Single-pass type I membrane protein.