CUEDC2 Q9H467

含CUE结构域蛋白2

功能描述

无论是否存在17β-雌二醇，均通过泛素化-蛋白酶体途径下调ESR1蛋白水平。也参与17β-雌二醇诱导的ESR1降解。通过类似的机制控制PGR蛋白水平。 {ECO:0000269|PubMed:17347654, ECO:0000269|PubMed:21572428}。

组织特异性

Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.

亚细胞定位

Cytoplasm