CTSD P07339

组织蛋白酶 D (EC 3.4.23.5) [裂解为：组织蛋白酶 D 轻链；组织蛋白酶 D 重链]

功能描述

酸性蛋白酶，在细胞内蛋白分解中具有活性。在ADAM30切割和激活后参与APP加工，导致APP降解 (PubMed:27333034)。参与多种疾病的发病机制，如乳腺癌，可能还包括阿尔茨海默病。 {ECO:0000269|PubMed:27333034}。

组织特异性

Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).

亚细胞定位

Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).