δ-连环蛋白-1 (钙黏蛋白相关Src底物) (CAS) (p120连环蛋白) (p120(ctn)) (p120(cas))
δ-连环蛋白-1 (钙黏蛋白相关Src底物) (CAS) (p120连环蛋白) (p120(ctn)) (p120(cas))
O60716功能描述
细胞-细胞黏附的关键调节因子，与C-、E-和N-cadherin结合并调节其细胞黏附特性，对其表面稳定性至关重要 (PubMed:14610055, PubMed:20371349)。通过与DSG3相互作用，促进DSG3在细胞-细胞连接处的定位和滞留 (PubMed:18343367)。除细胞-细胞黏附外，还通过包括ZBTB33/Kaiso2和GLIS2在内的多种转录因子，以及Rho家族GTPase和下游细胞骨架动力学活性来调节基因转录 (PubMed:10207085, PubMed:20371349)。既参与SRC诱导的细胞转化，也参与通过EGF、PDGF、CSF-1和ERBB2受体进行的配体诱导受体信号转导 (PubMed:17344476)。 {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}。
组织特异性
Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.
亚细胞定位
Cell junction, adherens junction
关键词