细胞毒性T淋巴细胞蛋白4 (细胞毒性T淋巴细胞相关抗原4) (CTLA-4) (CD抗原 CD152)
细胞毒性T淋巴细胞蛋白4 (细胞毒性T淋巴细胞相关抗原4) (CTLA-4) (CD抗原 CD152)
P16410功能描述
作为T细胞反应的主要负调节因子的抑制性受体 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017)。 作为诱饵受体起作用：CTLA4对其天然B7家族配体CD80和CD86的亲和力显著强于其同源刺激性共受体CD28的亲和力 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:28484017)。 {ECO:0000269|PubMed:11279501, ECO:0000269|PubMed:11279502, ECO:0000269|PubMed:1714933, ECO:0000269|PubMed:18641304, ECO:0000269|PubMed:28484017, ECO:0000303|PubMed:16551244}。
组织特异性
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
亚细胞定位
Cell membrane
关键词