CPZ Q66K79

羧肽酶Z (CPZ) (EC 3.4.17.-)

功能描述

特异性切割具有C端碱性氨基酸的底物和肽，尤其是含有C端Arg残基的底物和肽。可能通过切割某种未定义的protein来调节Wnt信号通路。可能在prohormone加工过程中的切割发挥作用。 {ECO:0000269|PubMed:11766880, ECO:0000269|PubMed:12417617, ECO:0000269|PubMed:33217972, ECO:0000269|PubMed:9099699}。

组织特异性

In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed.

亚细胞定位

Secreted, extracellular space