XIII型胶原α-1链 (COLXIIIA1)
XIII型胶原α-1链 (COLXIIIA1)
Q5TAT6功能描述
参与正常发育所需的细胞-基质和细胞-细胞粘附相互作用。可能参与肌纤维与基底膜之间的连接。可能在骨的软骨内骨化和肺的分支形态发生中发挥作用。结合肝素。在神经肌肉接头处，可能在乙酰胆碱受体聚集过程中发挥作用 (PubMed:26626625)。 {ECO:0000250|UniProtKB:Q9R1N9, ECO:0000269|PubMed:10865988, ECO:0000269|PubMed:11956183, ECO:0000269|PubMed:26626625}.
组织特异性
Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endometrial glands. Isoform 10: Expressed in muscle (PubMed:26626625).
亚细胞定位
Cell membrane
关键词