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COASY Q13057

双功能辅酶A合酶 (CoA synthase) (NBP) (POV-2) [包含:磷酸泛酰巯基乙胺腺苷酰转移酶 (EC 2.7.7.3) (脱磷酸辅酶A焦磷酸化酶) (泛酰巯基乙胺磷酸腺苷酰转移酶) (PPAT); 脱磷酸辅酶A激酶 (DPCK) (EC 2.7.1.24) (脱磷酸辅酶A激酶) (DPCOAK)]

蛋白质信息 (UniProt)

双功能辅酶A合酶 (CoA synthase) (NBP) (POV-2) [包含:磷酸泛酰巯基乙胺腺苷酰转移酶 (EC 2.7.7.3) (脱磷酸辅酶A焦磷酸化酶) (泛酰巯基乙胺磷酸腺苷酰转移酶) (PPAT); 脱磷酸辅酶A激酶 (DPCK) (EC 2.7.1.24) (脱磷酸辅酶A激酶) (DPCOAK)]

Q13057

功能描述

双功能酶,催化辅酶A生物合成途径的第四步,即4'-磷酸泛酰巯基乙胺的腺苷酸化,以及第五步,即脱磷酸辅酶A磷酸化为辅酶A。 {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:24360804}.

组织特异性

Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain.

亚细胞定位

Cytoplasm, cytosol

关键词

Alternative splicing ATP-binding Coenzyme A biosynthesis Cytoplasm Disease variant Kinase Mitochondrion Multifunctional enzyme Neurodegeneration Nucleotide-binding