CNR2 P34972

大麻素受体2 (CB-2) (CB2) (hCB2) (CX5)

功能描述

内源性大麻素2-花生四烯酸甘油的异三聚体G蛋白偶联受体，介导腺苷酸环化酶的抑制。可能在炎症反应、伤害性传递和骨稳态中发挥作用。 {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}.

组织特异性

Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.

亚细胞定位

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite