C型凝集素结构域家族2成员D (凝集素样NK细胞受体) (凝集素样转录本1) (LLT-1) (破骨细胞抑制凝集素)
C型凝集素结构域家族2成员D (凝集素样NK细胞受体) (凝集素样转录本1) (LLT-1) (破骨细胞抑制凝集素)
Q9UHP7功能描述
KLRB1的受体，保护靶细胞免受自然杀伤细胞介导的裂解 (PubMed:16339513, PubMed:20843815)。抑制破骨细胞形成 (PubMed:14753741, PubMed:15123656)。抑制骨吸收 (PubMed:14753741)。调节干扰素-gamma的释放 (PubMed:15104121)。结合高分子量硫酸化糖胺聚糖 (PubMed:15123656)。 {ECO:0000269|PubMed:14753741, ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:15123656, ECO:0000269|PubMed:16339513, ECO:0000269|PubMed:20843815}。
组织特异性
Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.
亚细胞定位
Cell membrane
关键词