C型凝集素结构域家族2成员A (角质形成细胞相关C型凝集素) (KACL) (增殖诱导的淋巴细胞相关受体) (PILAR)
C型凝集素结构域家族2成员A (角质形成细胞相关C型凝集素) (KACL) (增殖诱导的淋巴细胞相关受体) (PILAR)
Q6UVW9功能描述
主要在角质形成细胞上表达的膜结合蛋白，作为配体刺激自然杀伤（NK）细胞表面表达的激活受体NKp65/KLRF2 (PubMed:25510854)。从而促进对角质形成细胞的特异性免疫识别，导致自然杀伤细胞介导的细胞毒性 (PubMed:20194751)。也在调节T细胞扩增程度方面发挥作用 (PubMed:18550855)。 {ECO:0000269|PubMed:18550855, ECO:0000269|PubMed:20194751, ECO:0000269|PubMed:25510854}。
组织特异性
Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.
亚细胞定位
Cell membrane
关键词