CLDN7 O95471

克劳丁-7 (CLDN-7)

功能描述

在紧密连接特异性消除细胞间隙中起主要作用。 {ECO:0000250}。

组织特异性

Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.

亚细胞定位

Cell membrane