钙激活氯离子通道调节因子2 (EC 3.4.-.-) (钙激活氯离子通道家族成员2) (hCLCA2) (钙激活氯离子通道蛋白3) (CaCC-3) (hCaCC-3) [切割为：钙激活氯离子通道调节因子2，109 kDa形式；钙激活氯离子通道调节因子2，35 kDa形式]
钙激活氯离子通道调节因子2 (EC 3.4.-.-) (钙激活氯离子通道家族成员2) (hCLCA2) (钙激活氯离子通道蛋白3) (CaCC-3) (hCaCC-3) [切割为：钙激活氯离子通道调节因子2，109 kDa形式；钙激活氯离子通道调节因子2，35 kDa形式]
Q9UQC9功能描述
以钙依赖性方式在调节质膜氯离子电流及细胞粘附中发挥作用。参与鳞状上皮的基底细胞粘附和/或分层。可能在乳腺癌和结直肠癌中作为肿瘤抑制因子发挥作用。通过与ITGB4结合，在肺转移的初始阶段对细胞粘附起关键作用。 {ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.
组织特异性
Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; SUBCELLULAR LOCATION: [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.
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