钙激活氯离子通道调节蛋白 1 (EC 3.4.-.-) (钙激活氯离子通道家族成员 1) (hCLCA1) (钙激活氯离子通道蛋白 1) (CaCC-1) (hCaCC-1)
钙激活氯离子通道调节蛋白 1 (EC 3.4.-.-) (钙激活氯离子通道家族成员 1) (hCLCA1) (钙激活氯离子通道蛋白 1) (CaCC-1) (hCaCC-1)
A8K7I4功能描述
可能参与介导钙激活的氯离子电导。可能在杯状细胞化生、粘液分泌过多、囊性纤维化和AHR中发挥关键作用。可能参与杯状细胞粘液产生和/或分泌的调节。参与先天免疫应答中组织炎症的调节。可能作为肿瘤抑制因子发挥作用。诱导MUC5AC。 {ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}。
组织特异性
Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
亚细胞定位
Secreted, extracellular space
关键词