Cbp/p300相互作用转录激活因子4 (MSG1相关蛋白2) (MRG-2)
Cbp/p300相互作用转录激活因子4 (MSG1相关蛋白2) (MRG-2)
Q96RK1功能描述
作为TFAP2/AP-2的转录共激活因子。增强由雌激素受体介导的雌激素依赖性反式激活。可能通过破坏HIF1A与CREBBP的相互作用而作为HIF1A反式激活的抑制剂。可能参与血细胞、内皮细胞和乳腺上皮细胞发育和分化过程中的基因表达调控。 {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}。
组织特异性
Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis.
亚细胞定位
Nucleus
关键词