碳水化合物磺基转移酶9 (EC 2.8.2.-) (GalNAc-4-O-磺基转移酶2) (GalNAc-4-ST2) (GalNAc4ST-2) (N-乙酰半乳糖胺-4-O-磺基转移酶2)
碳水化合物磺基转移酶9 (EC 2.8.2.-) (GalNAc-4-O-磺基转移酶2) (GalNAc-4-ST2) (GalNAc4ST-2) (N-乙酰半乳糖胺-4-O-磺基转移酶2)
Q7L1S5功能描述
催化硫酸基团从3'-磷酸腺苷-5'-磷酸硫酸(PAPS)转移至N-聚糖和O-聚糖中非还原性N-乙酰半乳糖胺(GalNAc)残基的4位(PubMed:11139592, PubMed:11445554)。将硫酸转移至N-连接寡糖上序列GalNAc-beta-1,4GlcNAcbeta-R中末端beta-1,4-连接GalNAc的C-4羟基，以及软骨素和皮肤素中非末端beta-1,4-连接的GalNAc(PubMed:11445554)。通过介导糖蛋白激素黄体生成素和促甲状腺激素碳水化合物结构的硫酸化，参与其生物合成(PubMed:11139592, PubMed:11445554)。 {ECO:0000269|PubMed:11139592, ECO:0000269|PubMed:11445554}.; FUNCTION: [Isoform 2]: 对软骨素有活性，但对末端beta-1,4-连接的GalNAc无活性。 {ECO:0000269|PubMed:11139592}.
组织特异性
Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord.
亚细胞定位
[Isoform 1]: Golgi apparatus membrane
关键词