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CES2 O00748

可卡因酯酶 (EC 3.1.1.84) (羧酸酯酶2) (CE-2) (hCE-2) (EC 3.1.1.1) (甲基伞形酮乙酸酯脱乙酰酶2) (EC 3.1.1.56)

蛋白质信息 (UniProt)

可卡因酯酶 (EC 3.1.1.84) (羧酸酯酶2) (CE-2) (hCE-2) (EC 3.1.1.1) (甲基伞形酮乙酸酯脱乙酰酶2) (EC 3.1.1.56)

O00748

功能描述

参与异源生物质的解毒以及酯类和酰胺类前体药物的激活 (PubMed:9169443)。对可卡因、4-甲基伞形酮乙酸酯、海洛因和6-单乙酰吗啡的水解显示出高催化效率 (PubMed:9169443)。水解阿司匹林、具有大醇基团和小酰基基团的底物以及内源性脂质(如三酰甘油)(PubMed:28677105)。将单酰甘油转化为游离脂肪酸和甘油。水解2-花生四烯酸甘油和前列腺素 (PubMed:21049984)。 {ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:9169443, ECO:0000303|PubMed:28677105}。

组织特异性

Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.

亚细胞定位

Endoplasmic reticulum lumen

关键词

Alternative initiation Alternative splicing Direct protein sequencing Disulfide bond Endoplasmic reticulum Glycoprotein Hydrolase Lipid metabolism Proteomics identification Pyrrolidone carboxylic acid