CEP55 Q53EZ4

55 kDa中心体蛋白 (Cep55) (结肠癌上调蛋白6)

功能描述

在有丝分裂退出和胞质分裂中发挥作用 (PubMed:16198290, PubMed:17853893)。在胞质分裂期间将PDCD6IP和TSG101招募到中间体。成功完成胞质分裂所必需 (PubMed:17853893)。微管成核不需要 (PubMed:16198290)。在大脑和肾脏发育中发挥作用 (PubMed:28264986)。 {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}。

组织特异性

Expressed in embryonic brain (PubMed:28264986). Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex (PubMed:28264986). Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (at protein level) (PubMed:28264986, PubMed:28295209). Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.

亚细胞定位

Cytoplasm